Canadine

CAS: 522-97-4

Ref. TR-C175175

Informação sobre produto

• Nome: Canadine
• Sinónimos: 6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-, Berberine, 9-deoxy-16,17-dihydro- (6CI), Berbine, 9,10-dimethoxy-2,3-(methylenedioxy)- (7CI,8CI), Berberine, tetrahydro-, NSC 36351, NSC 94918, Tetrahydroberberine, Tetrahydroumbellatine, Xanthopuccine, dl-Canadine, dl-Tetrahydroberberine, (+/-)-Tetrahydroberberine, (±)-Tetrahydroberberine, 5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-, Berberine, 9-deoxy-16,17-dihydro-, Berberine, tetrahydro-, Berbine, 9,10-dimethoxy-2,3-(methylenedioxy)-, Tetrahydroberineper

Descrição

Applications Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling.
References Duchowicz, P., et al.: Bioorg. Med. Chem., 14, 5876 (2006), Sun., et al.: Br. J. Pharmcol., 158, 1302 (2009), Deeb, O., et al.: Chem. Biol. Drug Des., 76, 255 (2010),

• Marca: TRC

Propriedades químicas

• Peso molecular: 339.38
• Fórmula: C₂₀H₂₁NO₄
• Cor/forma: Neat
• InChI: InChI=1S/C20H21NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,8-9,16H,5-7,10-11H2,1-2H3
• Chave InChI: InChIKey=VZTUIEROBZXUFA-UHFFFAOYSA-N
• SMILES: COc1ccc2c(c1OC)CN1CCc3cc4c(cc3C1C2)OCO4