(3S)-4-Chloro-3-hydroxybutyronitrile

CAS: 127913-44-4

Ref. TR-C366605

Informação sobre produto

• Nome: (3S)-4-Chloro-3-hydroxybutyronitrile
• Sinónimos: (3S)-4-Chloro-3-hydroxybutanenitrile, (S)-4-Chloro-3-hydroxybutanenitrile, (S)-(-)-4-Chloro-3-hydroxybutyronitrile, (S)-4-Chloro-3-hydroxybutyronitrile, S-(-)-4-chloro-3-hydorxy butyronitrile, (3S)-4-chloro-3-hydorxybutyronitrile, (3R)-4-chloro-3-hydroxybutanenitrile, (3S)-4-chloro-3-hydroxybutanenitrile

Descrição

Applications (3S)-4-Chloro-3-hydroxybutyronitrile is used in various organic precursor syntheses. It is used in the synthesis of hydroxypyrrolidinones to by used as carbapenem precursors. Also used in the preparation of atorvastatin (A791750) precursors. Impurity in the synthesis of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
References Kanno, O. et al.: Hetero., 53, 173 (2000); Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006); Jiang, C. et al.: Lett. Org. Chem., 9, 520 (2012);

• Marca: TRC

Propriedades químicas

• Peso molecular: 119.55
• Fórmula: C₄H₆ClNO
• Cor/forma: Neat
• InChI: InChI=1S/C4H9ClO/c1-2-4(6)3-5/h4,6H,2-3H2,1H3/t4-/m0/s1
• Chave InChI: InChIKey=VNBFUGOVQMFIRN-BYPYZUCNSA-N
• SMILES: N#CC[C@H](O)CCl