4-Chloro-3-fluoroaniline

CAS: 367-22-6

Ref. TR-C367100

Informação sobre produto

• Nome: 4-Chloro-3-fluoroaniline
• Sinónimos: 4-Chloro-3-fluoro-aniline, 3-Fluoro-4-chloroaniline, 3-Fluoro-4-chlorobenzenamine, 4-Chloro-3-fluorobenzenamine, 4-Chloro-3-fluoro-benzeneamine, 4-Chloro-3-fluorophenylamine, 3-Fluoro-4-Chloroaniline, 4-Chloro-3-fluorobenzeneamine, Aniline, 4-chloro-3-fluoro-, Benzenamine, 4-chloro-3-fluoro-
• CAS: 367-22-6

Descrição

Applications 4-Chloro-3-fluoroaniline is used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate; a key intermediate towards phosphoindole inhibitors of HIV non-nucleoside reverse transcriptase. 4-Chloro-3-fluoroaniline is also used in the synthesis of 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib (D289540) which is an impurity of the tyrosine kinase inhibitor Gefitinib (G304000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mayes, B.A., et al.: Org. Process Res. Dev., 14, 1248 (2010); Lynch, T.J., et al.: N. Engl. J. Med., 350, 2129 (2004); Engelman, J.A., et al.: Science, 316, 1039 (2007); Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003)

• Marca: TRC

Propriedades químicas

• Peso molecular: 145.56
• Fórmula: C₆H₅ClFN
• Cor/forma: Neat
• InChI: InChI=1S/C6H5ClFN/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2
• Chave InChI: InChIKey=ACMJJQYSPUPMPN-UHFFFAOYSA-N
• SMILES: Nc1ccc(Cl)c(F)c1