iso-Colchicine-d3

CAS: 1246818-69-8

Ref. TR-C640006

Informação sobre produto

• Nome: iso-Colchicine-d3
• Sinónimos: N-[(7S)-5,6,7,10-Tetrahydro-1,2,3,9-tetramethoxy-10-oxobenzo[a]heptalen-7-yl]acetamide, Isocolchicine

Descrição

Applications An isotopically labelled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),

• Marca: TRC

Propriedades químicas

• Peso molecular: 402.46
• Fórmula: C₂₂H₂₂D₃NO₆
• Cor/forma: Neat
• InChI: InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-17(25)18(26-2)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1/i1D3
• Chave InChI: InChIKey=MDYALASTPGGXQH-AVSFSGARSA-N
• SMILES: [2H]C([2H])([2H])C(=O)N[C@H]1CCc2cc(OC)c(OC)c(OC)c2-c2ccc(=O)c(OC)cc21