Combretastatin A4 Phosphate Disodium Salt

CAS: 168555-66-6

Ref. TR-C643025

Informação sobre produto

• Nome: Combretastatin A4 Phosphate Disodium Salt
• Sinónimos: disodium;[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate
• Marca: TRC
• Descrição: Applications Phosphorylated Combretastatin, a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.References Hamel, E., et al.: Biochem. Pharmacol., 32, 3863 (1983), Chaplin, D.J., et al.: Br. J. Cancer, 74, S86, (1996)

Propriedades químicas

• Peso molecular: 440.29
• Fórmula: C₁₈H₁₉O₈P·2Na
• Cor/forma: Neat
• InChI: InChI=1S/C18H21O8P.2Na/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3;;/h5-11H,1-4H3,(H2,19,20,21);;/q;2*+1/p-2/b6-5-
• Chave InChI: InChIKey=VXNQMUVMEIGUJW-XNOMRPDFSA-L
• SMILES: COc1ccc(/C=C\c2cc(OC)c(OC)c(OC)c2)cc1OP(=O)(O[Na])O[Na]