1,5-Cyclooctadiene(pyridine)(tricyclohexylphosphine)iridium(I) Hexafluorophosphate

CAS: 64536-78-3

Ref. TR-C984570

Informação sobre produto

• Nome: 1,5-Cyclooctadiene(pyridine)(tricyclohexylphosphine)iridium(I) Hexafluorophosphate
• Sinónimos: (1,5-Cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(1+) hexafluorophosphate, (1,5-Cyclooctadiene)pyridine(tricyclohexylphosphine)iridium hexafluorophosphate, Crabtree's Catalyst, Felkin-Crabtree catalyst, (?4-1,5-Cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate, (1,5-Cyclohexadiene)pyridine(tricyclohexylphosphine)iridium hexafluorophosphate, (1,5-Cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate, (1,5-cyclooctadiene)(pyrid.)(tric.hexyl-phosphine)irid(I)pf6, (Tricyclohexyphosphine)(1,5-cyclooctadiene)(pyridine)iridium(I) hexafluorophosphate, (η⁴-1,5-Cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate, 1,5-Cyclooctadiene, iridium complex, Crabtree'S Catalyst, Crabtrees Catalyst, Iridium(1+), [(1,2,5,6-η)-1,5-cyclooctadiene](pyridine)(tricyclohexylphosphine)-, hexafluorophosphate(1-), Iridium(1+), [(1,2,5,6-η)-1,5-cyclooctadiene](pyridine)(tricyclohexylphosphine)-, hexafluorophosphate(1-) (1:1), Phosphate(1-), hexafluoro-, [(1,2,5,6-η)-1,5-cyclooctadiene](pyridine)(tricyclohexylphosphine)iridium(1+), Phosphine, tricyclohexyl-, iridium complex, [(1,2,5,6-η)-1,5-Cyclooctadiene](pyridine)(tricyclohexylphosphine)iridium(1+) hexafluorophosphate(1-), (Tricyclohexylphosphine)(1,5-cyclooctadiene)(pyridine)iridium(I)hexafluorophosphate

Descrição

Applications 1,5-Cyclooctadiene(pyridine)(tricyclohexylphosphine)iridium(I) Hexafluorophosphate is a catalyst that is used in the synthesis of 4α,5-Dihydro Simvastatin (D450010). 4α,5-Dihydro Simvastatin is an impurity in the synthesis of Simvastatin (S485000), a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),

• Marca: TRC

Propriedades químicas

• Peso molecular: 802.88
• Fórmula: C₃₁H₄₈F₆IrNP₂
• Cor/forma: Neat
• InChI: InChI=1S/C18H33P.C8H10.C5H5N.F6P.Ir/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18;1-2-4-6-8-7-5-3-1;1-2-4-6-5-3-1;1-7(2,3,4,5)6;/h16-18H,1-15H2;1,8H,2,4-5,7H2;1-5H;;/q;;;-6;+1