(2'R)​-2'-​Deoxy-​2'-​fluoro-​2'-​methyl-uridine 5'-​Triphosphate Triethylammonium Salt

CAS: 1015073-42-3

Ref. TR-D235370

Informação sobre produto

• Nome: (2'R)​-2'-​Deoxy-​2'-​fluoro-​2'-​methyl-uridine 5'-​Triphosphate Triethylammonium Salt
• Sinónimos: Sofosbuvir Impurity, RO 2433 Triphosphate Triethylammonium Salt
• CAS: 1015073-42-3

Descrição

Stability Hygroscopic
Applications (2'R)​-2'-​Deoxy-​2'-​fluoro-​2'-​methyl-uridine 5'-​Triphosphate Tetrasodium Salt is an impurity of Sofosbuvir (P839640) which is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate.
References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010);

• Marca: TRC

Propriedades químicas

• Peso molecular: 803.73
• Fórmula: C₂₈H₆₁FN₅O₁₄P₃
• Cor/forma: Off White Solid
• InChI: InChI=1S/C10H16FN2O14P3.C6H13N/c1-10(11)7(15)5(25-8(10)13-3-2-6(14)12-9(13)16)4-24-29(20,21)27-30(22,23)26-28(17,18)19;1-4-7(5-2)6-3/h2-3,5,7-8,15H,4H2,1H3,(H,20,21)(H,22,23)(H,12,14,16)(H2,17,18,19);4-5H2,1-3H3/t5-,7?,8-,10-;/m1./s1
• Chave InChI: InChIKey=SYYDSNWTJCRYSF-AAXBDWBCSA-N
• SMILES: C[C@@]1(F)C(O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O[C@H]1n1ccc(=O)[nH]c1=O.C[C]N(CC)CC