2'-Deoxy-6-thio Guanosine-13C, 15N2

CAS: 789-61-7

Ref. TR-D281652

Informação sobre produto

• Nome: 2'-Deoxy-6-thio Guanosine-13C, 15N2
• Sinónimos: 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine-6(1H)-thione-13C, 15N2, 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercaptopurine-13C, 15N2, 2'-Deoxythioguanosine-13C, 15N2, 2'-Desoxy-6-thioguanosine-13C, 15N2, NSC 71261-13C, 15N2, TGdR-13C, 15N2, Thioguanine Deoxyriboside-13C, 15N2, β-Thioguanine Deoxyriboside-13C
• Marca: TRC

Descrição

Applications 2'-Deoxy-6-thio Guanosine-13C, 15N2 is labelled 2'-Deoxy-6-thio Guanosine (D281650) which is a Guanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.
References Momparler, R.L. et al.: Cancer Treat. Rep., 62, 135 (1978); Krynetskaia, N.F. et al.: Mol. Pharmacol., 56, 841 (1999)

Propriedades químicas

• Peso molecular: 286.286
• Fórmula: CC₉H₁₃₁₅N₂N₃O₃S
• Cor/forma: Neat
• InChI: InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1/i10+1,11+1,14+1
• Chave InChI: InChIKey=SCVJRXQHFJXZFZ-CWPRTZMXSA-N
• SMILES: [15NH2][13c]1[nH]c2c(ncn2[C@H]2C[C@H](O)[C@@H](CO)O2)c(=S)[15n]1