O-Deshydroxyethyl Bosentan

CAS: 174227-14-6

Ref. TR-D290485

Informação sobre produto

• Nome: O-Deshydroxyethyl Bosentan
• Sinónimos: Benzenesulfonamide, N-[1,6-dihydro-5-(2-methoxyphenoxy)-6-oxo[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-, 4-tert-Butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide, N-[1,6-Dihydro-5-(2-methoxyphenoxy)-6-oxo[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide, (4-(tert-butyl)-N-[6-hydroxy-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl]benzenesulfonamide), Bosentan Related Compound B
• CAS: 174227-14-6

Descrição

Impurity Bosentan USP Related Compound B
Applications O-Deshydroxyethyl Bosentan (Bosentan USP Related Compound B) is an impurity of Bosentan (B675900); a mixed endothelin receptor antagonist. Used as a vasodilator and antihypertensive.
References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994); Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996); Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996); Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)

• Marca: TRC

Propriedades químicas

• Peso molecular: 507.56
• Fórmula: C₂₅H₂₅N₅O₅S
• Cor/forma: Beige
• InChI: InChI=1S/C25H25N5O5S/c1-25(2,3)16-10-12-17(13-11-16)36(32,33)30-21-20(35-19-9-6-5-8-18(19)34-4)24(31)29-23(28-21)22-26-14-7-15-27-22/h5-15H,1-4H3,(H2,28,29,30,31)
• Chave InChI: InChIKey=REEANFGHAAWSIZ-UHFFFAOYSA-N
• SMILES: COc1ccccc1Oc1c(O)nc(-c2ncccn2)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1