N-Desmethyl-N-methoxycarbonyl-10-oxocodeinone

Ref. TR-D291090

Informação sobre produto

• Nome: N-Desmethyl-N-methoxycarbonyl-10-oxocodeinone
• Sinónimos: methyl (4S,7aR,12bS)-9-methoxy-7,13-dioxo-2,4,4a,7a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-3-carboxylate

Descrição

Applications N-Desmethyl-N-methoxycarbonyl-10-oxocodeinone is an impurity in the synthesis of N-Allyldihydro-8,10,14-trihydroxynormorphinone (A549610), an impurity of Naloxone (HCl salt, N285000) which is a specific opioid antagonist and narcotic antagonist.
References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967); McNicholas, L.F., et al.: Drugs, 27, 81 (1984); Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985); Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)

• Marca: TRC

Propriedades químicas

• Peso molecular: 355.341
• Fórmula: C₁₉H₁₇NO₆
• Cor/forma: Neat
• InChI: InChI=1S/C19H17NO6/c1-24-12-6-3-9-13-16(12)26-17-11(21)5-4-10-14(15(9)22)20(18(23)25-2)8-7-19(10,13)17/h3-6,10,14,17H,7-8H2,1-2H3/t10?,14-,17-,19-/m0/s1
• Chave InChI: InChIKey=QZTLJPXBJGGVPY-ZYVDJXAMSA-N
• SMILES: COC(=O)N1CC[C@]23c4c5ccc(OC)c4O[C@H]2C(=O)C=CC3[C@H]1C5=O