Dihydroergotamine (+)-Tartrate Salt (2:1)

CAS: 5989-77-5

Ref. TR-D450653

Informação sobre produto

• Nome: Dihydroergotamine (+)-Tartrate Salt (2:1)
• Sinónimos: Dihydroergotamine tartrate, Bis[(6aR,9R,10aR)-N-[(2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide] (2R,3R)-2,3-dihydroxybutanedioate, 5'-Benzyl-12'-Hydroxy-2'-Methyl-3',6',18-Trioxo-9,10-Dihydroergotaman 2,3-Dihydroxybutanedioate (1:1), 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine, ergotaman-3′,6′,18-trione deriv., 9,10-Dihydroergotamine tartrate, Bis(5'alpha-benzyl-9,10alpha-dihydro-12'-hydroxy-2'-methylergotaman-3',6',18-trione) (R-(R*,R*))-tartrate, Dihydroergotamine tartrate (2:1), Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)-, (5′α,10α)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1), Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)-, (5′α,10α)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) (salt), Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)-, (5′α,10α)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt), Ergotamine, dihydro-, tartrate (2:1)(salt), Indolo[4,3-fg]quinoline, ergotaman-3′,6′,18-trione deriv.
• CAS: 5989-77-5

Descrição

Applications Dihydroergotamine (+)-tartrate salt is a vascular serotonin receptor activator. In addition, it has been shown to induce lung cancer cell death through apoptosis and mitophagy.
References Gohil, V. et al.: Nature Biotech., 28, 249 (2010); Chang, S. et al.: Chemother., 61, 304 (2016); de Marees, et al.: Eur. J. Clin. Pharmacol., 30, 685 (1986),

• Marca: TRC

Propriedades químicas

• Peso molecular: 1317.44
• Fórmula: (C₃₃H₃₇N₅O₅)•C₄H₆O₆
• Cor/forma: White
• InChI: 5-1(3(7)8)2(6)4(9)10/h2*3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39), 1-,2-/m111/s1, InChI=1S/2C33H37N5O5.C4H6O6/c2*1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32, 1-2,5-6H,(H,7,8)(H,9,10)/t2*21-,23-,25-,26+,27+,32-,33+
• Chave InChI: InChIKey=QCBGTQHGJQLHSY-ZQYJFMNESA-N
• SMILES: CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21.O=C(O)[C@H](O)[C@@H](O)C(=O)O