3,4-Dihydro-1-naphthaleneacetyl Chloride

CAS: 114949-13-2

Ref. TR-D452195

Informação sobre produto

• Nome: 3,4-Dihydro-1-naphthaleneacetyl Chloride
• CAS: 114949-13-2

Descrição

Applications 3,4-Dihydro-1-naphthaleneacetyl Chloride is an intermediate used in the synthesis of 4-Amino-1-tert-butyl-3-(1’-naphthylmethyl)pyrazolo[3,4-d]pyrimidine (A603003), which is a highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase;Also, it is used in the synthesis of water-soluble chymotrypsin inhibitors.
References Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999), Davies, S., et al.: Biochem. J., 351, 95 (2000), Regan, J., et al.: J. Med. Chem., 45, 2994 (2002), Bain, J., et al.: Biochem. J., 371, 199 (2003), Kuma, Y., et al.: J. Biol. Chem., 280, 19472 (2005);Yokoo, N., et al.: Yakugaku Zasshi, 107, 732-737 (1987)

• Marca: TRC

Propriedades químicas

• Peso molecular: 206.67
• Fórmula: C₁₂H₁₁ClO
• Cor/forma: Neat
• InChI: InChI=1S/C12H11ClO/c13-12(14)8-10-6-3-5-9-4-1-2-7-11(9)10/h1-2,4,6-7H,3,5,8H2
• Chave InChI: InChIKey=IOESOTJLHGNTNA-UHFFFAOYSA-N
• SMILES: O=C(Cl)CC1=CCCc2ccccc21