3-(Dimethylamino)-1-(1-naphthalenyl)-1-propanone Hydrochloride-D6

CAS: 5409-58-5

Ref. TR-D461196

Informação sobre produto

• Nome: 3-(Dimethylamino)-1-(1-naphthalenyl)-1-propanone Hydrochloride-D6
• Sinónimos: 3-(bis(methyl-d3)amino)-1-(naphthalen-1-yl-2,3-d2)propan-1-one hydrochloride, (3-Dimethylamino)-1''-Propionapthone Hydrochloride, 1'-Propionaphthone,3-(dimethylamino)-, hydrochloride, 1-Propanone,3-(dimethylamino)-1-(1-naphthalenyl)-, hydrochloride, 3-Dimethylamino-1-(naphthalen-1-yl)propan-1-one hydrochloride, 1-Propanone, 3-(dimethylamino)-1-(1-naphthalenyl)-, hydrochloride (1:1)

Descrição

Applications 3-(Dimethylamino)-1-(1-naphthalenyl)-1-propanone Hydrochloride-D6 is a reagent in the synthesis of Bedaquiline-d6 (Mixture of Diastereomers) (B119552) which is the labelled analog of Bedaquiline, a diarylquinoline derivative that acts as a mycobacterial inhibitor. Bedaquiline shows promise as potential drug in the treatment of tuberculosis.
References de Jonge M.R. et al.: Proteins, 67, 971 (2007); Diacon A.H. et al.: N. Eng. J. Med., 360, 2397 (2009);

• Marca: TRC

Propriedades químicas

• Peso molecular: 269.8
• Fórmula: C₁₅H₁₁D₆NO•ClH
• Cor/forma: Neat
• InChI: InChI=1S/C15H17NO.ClH/c1-16(2)11-10-15(17)14-9-5-7-12-6-3-4-8-13(12)14;/h3-9H,10-11H2,1-2H3;1H/i1D3,2D3,5D,9D
• Chave InChI: InChIKey=GUTDWEKYWTXJGD-TXHXQZCNSA-N
• SMILES: Cl.[2H]C([2H])([2H])N(CCC(=O)c1cccc2ccccc12)C([2H])([2H])[2H]