5-(N,N-Dimethyl)-amiloride-d6 Hydrochloride

CAS: 2235-97-4

Ref. TR-D470572

Informação sobre produto

• Nome: 5-(N,N-Dimethyl)-amiloride-d6 Hydrochloride
• Sinónimos: 3-Amino-N-(aminoiminomethyl)-6-chloro-5-(dimethylamino)-pyrazinecarboxamide-d6 Monohydrochloride, N-Amidino-3-amino-6-chloro-5-(dimethylamino)-pyrazinecarboxamide-d6 Monohydrochloride, (3-Amino-5-dimethylamino-6-chloropyrazinoyl)guanidine-d6 Hydrochloride, Pyrazinecarboxamide,3-amino-N-(aminoiminomethyl)-6-chloro-5-(dimethylamino)-, monohydrochloride(9CI), Pyrazinecarboxamide, N-amidino-3-amino-6-chloro-5-(dimethylamino)-,monohydrochloride (8CI), (3-Amino-5-dimethylamino-6-chloropyrazinoyl)guanidinehydrochloride

Descrição

Applications 5-(N,N-Dimethyl)-amiloride-d6 Hydrochloride is an isotopic analog of 5-(N,N-Dimethyl)-amiloride Hydrochloride (D470570), which has been used to investigate biochemical processes related to the circadian clock in mouse and human cell lines. It can also inhibit sodium-hydrogen exchangers (NHE). NHEs regulate sodium and pH in various tissues.
References Isojima, Y., et al.: Proc. Natl. Acad. Sci. USA 106, 15744 (2009); Masereel, B., et al.: Eur J Med Chem 38, 547 (2003)

• Marca: TRC

Propriedades químicas

• Peso molecular: 299.09352
• Fórmula: C₈H₆D₆ClN₇O•(HCl)
• Cor/forma: Neat
• InChI: InChI=1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H/i1D3,2D3
• Chave InChI: InChIKey=IIUPTHVVXMBJMQ-TXHXQZCNSA-N
• SMILES: Cl.[2H]C([2H])([2H])N(c1nc(N)c(C(=O)NC(=N)N)nc1Cl)C([2H])([2H])[2H]