(2R,4S)-2-(1,1-Dimethylethyl)-4-methyl-1,3-oxathiolan-5-one

CAS: 476371-85-4

Ref. TR-D471958

Informação sobre produto

• Nome: (2R,4S)-2-(1,1-Dimethylethyl)-4-methyl-1,3-oxathiolan-5-one
• Sinónimos: (2R,4S)-2-(t-Butyl)-4-methyl-1,3-oxathiolan-5-one
• Marca: TRC

Descrição

Applications (2R,4S)-2-(1,1-Dimethylethyl)-4-methyl-1,3-oxathiolan-5-one is an intermediate in synthesizing (R)-(+)-Thiolactomycin (T350880). It is a natural product inhibitor of β-Ketoacyl-AcpM Synthase A (KasA). It inhibits the synthesis of mycolic acid which is a major cell wall component of Mycobacterium tuberculosis. Also an inhibitor of D-Aspartate oxidase (DDO).
References Kapilashrami, K., et al.: J. Biol. Chem., 288, 6045 (2013); Paneerselvam, V., et al.: J. Pharm. Res., 4, 4618 (2011); Katane, M., et al.: Biochimie, 92, 1371 (2010)

Propriedades químicas

• Peso molecular: 174.26
• Fórmula: C₈H₁₄O₂S
• Cor/forma: Neat
• InChI: InChI=1S/C8H14O2S/c1-5-6(9)10-7(11-5)8(2,3)4/h5,7H,1-4H3/t5-,7+/m0/s1
• Chave InChI: InChIKey=BBCNMYQDVCRBRW-CAHLUQPWSA-N
• SMILES: C[C@@H]1S[C@H](C(C)(C)C)OC1=O