N-[(1,1-Dimethylethoxy)carbonyl]glycyl-4,4-difluoro-L-prolinamide

CAS: 1448440-48-9

Ref. TR-D489140

Informação sobre produto

• Nome: N-[(1,1-Dimethylethoxy)carbonyl]glycyl-4,4-difluoro-L-prolinamide
• Sinónimos: tert-butyl N-[2-[(2S)-2-carbamoyl-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamate

Descrição

Applications N-[(1,1-Dimethylethoxy)carbonyl]glycyl-4,4-difluoro-L-prolinamide is a reagent in the synthesis of (S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide (UAMC1110) (S687910) which is a useful research chemical and a fibroblast activation protein inhibitor displaying low nanomolar inhibitory potency and high selectivity against related dipeptidyl peptidases.
References De D., et al.: ACS Med. Chem., 10, 1173 (2019); Simon, P., et al.: ACS Chem. Biol., 13, 3333 (2018); De D., et al.: ACS Med. Chem. Lett., 10, 1173 (2019)

• Marca: TRC

Propriedades químicas

• Peso molecular: 307.294
• Fórmula: C₁₂H₁₉F₂N₃O₄
• Cor/forma: Neat
• InChI: InChI=1S/C12H19F2N3O4/c1-11(2,3)21-10(20)16-5-8(18)17-6-12(13,14)4-7(17)9(15)19/h7H,4-6H2,1-3H3,(H2,15,19)(H,16,20)/t7-/m0/s1
• Chave InChI: InChIKey=QCIPQLRWQDVVQZ-ZETCQYMHSA-N
• SMILES: CC(C)(C)OC(=O)NCC(=O)N1CC(F)(F)C[C@H]1C(N)=O