Dorsomorphin Dihydrochloride

CAS: 1219168-18-9

Ref. TR-D534910

Informação sobre produto

• Nome: Dorsomorphin Dihydrochloride
• Sinónimos: 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride

Descrição

Applications Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.
References Shen, Q.W., Gerrard, D.E., Du, M.: Meat Sci., 78, 323 (2008); Yu, P., et. al.: Nat. Chem. Biol., 4, 33 (2008); Kim, H., et. al.: J. Biol. Chem., 283, 3731 (2008)

• Marca: TRC

Propriedades químicas

• Peso molecular: 472.41
• Fórmula: C₂₄H₂₅N₅OClH
• Cor/forma: Neat
• InChI: InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H
• Chave InChI: InChIKey=XHBVYDAKJHETMP-UHFFFAOYSA-N
• SMILES: c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1