7-Epi-10-oxo Docetaxel

CAS: 162784-72-7

Ref. TR-E588610

Informação sobre produto

• Nome: 7-Epi-10-oxo Docetaxel
• Sinónimos: 4-epi-6-Oxodocetaxel, 5ß,20-Epoxy-1,7a-dihydroxy-9,10-dioxotax-11-ene-2a,4,13a-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoate, 10-Deoxy-10-oxo-7-epidocetaxel, Docetaxel Trihydrate Imp D (EP), 4-epi-6-Oxodocetaxel,Benzenepropanoic acid, ß-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-, (2aR,4R,4aS,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5,6-dioxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (aR,ßS)-, Benzenepropanoic acid, ß-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5,6-dioxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aa,4a,4aß,9a(aR*,ßS*),11a,12a,12aa,12ba]]-, (2aR,4R,4aS,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4,9,11,12,12b-pentahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5,6-dione 12b-acetate 12-benzoate 9-ester with (2R,3S)-N-tert-butoxycarbonyl-3-phenylisoserine, (2b,5b,7a,13a)-4-Acetoxy-13-(((2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl)oxy)-1,7-dihydroxy- 9,10-dioxo-5,20-epoxytax-11-en-2-yl Benzoate, Docetaxel Impurity D, 10-Oxo-7-Epi-Docetaxel, 7-Epi-10-Oxo-Docetaxel (Docetaxel Impurity D)

Descrição

Impurity Docetaxel EP Impurity D
Applications 7-Epi-10-oxo Docetaxel (Docetaxel EP Impurity D) is a Docetaxel (D494420) injection impurity D.
References Hanna, I., et al.: Cancer Res., 60, 3440 (2000), Bournique, B., et al.: Br. J. Clin. Pharmacol., 52, 53 (2001), McFadyen, M., et al.: Biochem. Pharmacol., 62, 207 (2001), Vasu Dev, R., et al.: J. Pharm. Biomed. Anal., 40, 614 (2006),

• Marca: TRC

Propriedades químicas

• Peso molecular: 805.86
• Fórmula: C₄₃H₅₁NO₁₄
• Cor/forma: White Solid
• InChI: InChI=1S/C43H51NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30,32-33,35,46,48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27+,28+,30-,32+,33-,35-,41+,42-,43+/m0/s1
• Chave InChI: InChIKey=ZOLQDWANVNOXBK-JSBGVCCUSA-N
• SMILES: CC(=O)O[C@@]12CO[C@@H]1C[C@@H](O)[C@@]1(C)C(=O)C(=O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@H]21)C3(C)C