(7α,11α,12α,17α)-11,12-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic Acid Lactone, Methyl Ester

CAS: 192704-82-8

Ref. TR-E589325

Informação sobre produto

• Nome: (7α,11α,12α,17α)-11,12-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic Acid Lactone, Methyl Ester
• Sinónimos: Pregn-4-ene-7,21-dicarboxylic acid, 11,12-epoxy-17-hydroxy-3-oxo-, 21,17-lactone, 7-methyl ester, (7α,11α,12α,17α)-, Pregn-4-ene-7,21-dicarboxylic acid, 11,12-epoxy-17-hydroxy-3-oxo-, γ-lactone, methyl ester, (7α,11α,12α,17α)- (9CI), Spiro[11,12-epoxy-17H-cyclopenta[a]phenanthrene-17,2'(3'H)-furan], pregn-4-ene-7,21-dicarboxylic acid deriv., 11α,12α-Epoxy-7α-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone, 9α,11α-Deepoxy-11α,12α-epoxyeplerenone, (7Alpha,11Alpha,12Alpha,17Alpha)-11,12-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic Acid Lactone, Methyl Ester, Pregn-4-ene-7,21-dicarboxylic acid, 11,12-epoxy-17-hydroxy-3-oxo-, 21,17-lactone, 7-methyl ester, (7α,11α,12α,17α)-, Pregn-4-ene-7,21-dicarboxylic acid, 11,12-epoxy-17-hydroxy-3-oxo-, γ-lactone, methyl ester, (7α,11α,12α,17α)- (9CI), Spiro[11,12-epoxy-17H-cyclopenta[a]phenanthrene-17,2'(3'H)-furan], pregn-4-ene-7,21-dicarboxylic acid deriv., 11α,12α-Epoxy-7α-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone
• Marca: TRC
• Descrição: Applications (7α,11α,12α,17α)-11,12-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic Acid Lactone, Methyl Ester is an impurity of eplerenone (E588775). Eplerenone is a selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.References de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005),

Propriedades químicas

• Peso molecular: 414.491
• Fórmula: C₂₄H₃₀O₆
• Cor/forma: Neat
• InChI: InChI=1S/C24H30O6/c1-22-7-4-13(25)10-12(22)11-14(21(27)28-3)17-15-5-8-24(9-6-16(26)30-24)23(15,2)20-19(29-20)18(17)22/h10,14-15,17-20H,4-9,11H2,1-3H3/t14-,15+,17+,18-,19+,20+,22+,23-,24-/m1/s1