7-[(4-Ethyl-1-piperazinyl)[4-(trifluoromethyl)phenyl]methyl]-8-quinolinol

CAS: 315698-17-0

Ref. TR-E900485

Informação sobre produto

• Nome: 7-[(4-Ethyl-1-piperazinyl)[4-(trifluoromethyl)phenyl]methyl]-8-quinolinol
• Sinónimos: ML311
• CAS: 315698-17-0

Descrição

Applications 7-[(4-Ethyl-1-piperazinyl)[4-(trifluoromethyl)phenyl]methyl]-8-quinolinol is a selective inhibitor of the protein -protein interaction of Mcl-1 inhibitors and also a potential antitumor agents. Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
References Richard, D. J., et al.: Bioorg. Med. Chem., 21, 6642 (2013); Bruncko, M., et al.: J. Med. Chem., 58, 2180 (2015)

• Marca: TRC

Propriedades químicas

• Peso molecular: 415.45
• Fórmula: C₂₃H₂₄F₃N₃O
• Cor/forma: Yellow Solid
• InChI: InChI=1S/C23H24F3N3O/c1-2-28-12-14-29(15-13-28)21(17-5-8-18(9-6-17)23(24,25)26)19-10-7-16-4-3-11-27-20(16)22(19)30/h3-11,21,30H,2,12-15H2,1H3
• Chave InChI: InChIKey=NGAPBLRRJSKIRT-UHFFFAOYSA-N
• SMILES: CCN1CCN(C(c2ccc(C(F)(F)F)cc2)c2ccc3cccnc3c2O)CC1