5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

CAS: 403811-55-2

Ref. TR-E925745

Informação sobre produto

• Nome: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
• Sinónimos: 10058-F4, 10058F4, (E)-5-(4-Ethylbenzylidene)-2-thioxothiazolidin-4-one, (5E)-5-(4-Ethylbenzylidene)-2-thioxo-1,3-thiazolidin-4-one, (5Z)-5-(4-ethylbenzylidene)-2-thioxo-1,3-thiazolidin-4-one, 4(5H)-thiazolone, 5-[(4-ethylphenyl)methylene]-2-mercapto-, (5E)-, 4(5H)-thiazolone, 5-[(4-ethylphenyl)methylene]-2-mercapto-, (5Z)-, 4-Thiazolidinone, 5-[(4-ethylphenyl)methylene]-2-thioxo-, 4-thiazolidinone, 5-[(4-ethylphenyl)methylene]-2-thioxo-, (5E)-

Descrição

Applications 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone is a c-Myc inhibitor that specifically inhibits c-Myc-Max interaction, function and prevents transactivation of c-Myc target gene expression. The use of 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone is a potential antileukamic approach due to its affects on multiple cellular activities in acute myeloid leukemia (AML).
References Yin, X., et. al.: Oncogene, 22, 6151 (2003); Huang, M., et. al.: Exp. Hematol, 34, 1480 (2006)

• Marca: TRC

Propriedades químicas

• Peso molecular: 249.35
• Fórmula: C₁₂H₁₁NOS₂
• Cor/forma: Yellow to Dark Beige Solid
• InChI: InChI=1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
• Chave InChI: InChIKey=SVXDHPADAXBMFB-JXMROGBWSA-N
• SMILES: CCc1ccc(/C=C2/SC(=S)NC2=O)cc1