Everolimus

CAS: 159351-69-6

Ref. TR-E945400

Informação sobre produto

• Nome: Everolimus
• Sinónimos: Rapamycin, 42-O-(2-hydroxyethyl)-, 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv., 42-O-(2-Hydroxyethyl)rapamycin, 40-O-(2-Hydroxyethyl)rapamycin, Afinitor, Afinitor Disperz, Certican, RAD, RAD 001, SDZ-RAD, XIENCE V, Xience
• Marca: TRC
• Descrição: Impurity Everolimus EP Impurity CStability HygroscopicApplications Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),

Propriedades químicas

• Peso molecular: 958.22
• Fórmula: C₅₃H₈₃NO₁₄
• Pureza: ~90%
• Cor/forma: Neat
• InChI: InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
• Chave InChI: InChIKey=HKVAMNSJSFKALM-ADNAJIBWSA-N
• SMILES: CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OCCO)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=C/C=C/C=C/1C