2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene

CAS: 898566-17-1

Ref. TR-F532295

Informação sobre produto

• Nome: 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
• Sinónimos: 2-(4-Fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene, 2-((5-Iodo-2-Methylphenyl)Methyl)-5-(4-Fluorophenyl)Thiophene, 2-(5-Iodo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene, 5-(5-Iodo-2-methylbenzyl)-2-(4-fluorophenyl)thiophene, Thiophene, 2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]-

Descrição

Applications 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene is an antidiabetic agent and a Canagliflozin (C175190) intermediate. Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and a candidate for the treatment of type 2 diabetes and obesity.
References Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.: Clin. Invest., 1, 145 (2011);

• Marca: TRC

Propriedades químicas

• Peso molecular: 408.27
• Fórmula: C₁₈H₁₄FIS
• Cor/forma: Neat
• InChI: InChI=1S/C18H14FIS/c1-12-2-7-16(20)10-14(12)11-17-8-9-18(21-17)13-3-5-15(19)6-4-13/h2-10H,11H2,1H3
• Chave InChI: InChIKey=MGXZKAYHSITHMW-UHFFFAOYSA-N
• SMILES: Cc1ccc(I)cc1Cc1ccc(-c2ccc(F)cc2)s1