1-(4-Fluorophenyl)-N-[3-(1H-imidazol-1-yl)propyl]-2,2-dimethyl-cyclopropanecarboxamide

CAS: 1434927-54-4

Ref. TR-F596160

Informação sobre produto

• Nome: 1-(4-Fluorophenyl)-N-[3-(1H-imidazol-1-yl)propyl]-2,2-dimethyl-cyclopropanecarboxamide
• Sinónimos: 1-(4-fluorophenyl)-N-(3-imidazol-1-ylpropyl)-2,2-dimethylcyclopropane-1-carboxamide

Descrição

Applications 1-(4-Fluorophenyl)-N-[3-(1H-imidazol-1-yl)propyl]-2,2-dimethyl-cyclopropanecarboxamide has therapeutic uses. It is synthesized from 1-(4-Fluorophenyl)-2,2-dimethyl-cyclopropanecarboxylic Acid (F595430), which is used as a reagent in the synthesis of a new class of 7-azaindole analogs of MK-7246 (M425045) as potent and selective CRTH2 antagonists for the treatment of respiratory diseases.
References Simard, D., et al.: Bioorg. Med. Chem. Lett., 21, 841 (2011); Molinaro, C., et al.: J. Org. Chem., 77, 2299 (2012); Gervais, F.G., et al.: Mol. Pharmacol., 79, 69 (2011); Gallant, M, et al.: Bioorg. Med. Chem. Lett., 21, 288 (2011);

• Marca: TRC

Propriedades químicas

• Peso molecular: 315.385
• Fórmula: C₁₈H₂₂FN₃O
• Cor/forma: Neat
• InChI: InChI=1S/C18H22FN3O/c1-17(2)12-18(17,14-4-6-15(19)7-5-14)16(23)21-8-3-10-22-11-9-20-13-22/h4-7,9,11,13H,3,8,10,12H2,1-2H3,(H,21,23)
• Chave InChI: InChIKey=MBTXJGAIMKPLBE-UHFFFAOYSA-N
• SMILES: CC1(C)CC1(C(=O)NCCCn1ccnc1)c1ccc(F)cc1