6-​Fluoro-​3-​[(trimethylsilyl)​oxy]​-2-​pyrazinecarboxamide

CAS: 1613031-87-0

Ref. TR-F597083

Informação sobre produto

• Nome: 6-​Fluoro-​3-​[(trimethylsilyl)​oxy]​-2-​pyrazinecarboxamide
• Sinónimos: 6-Fluoro-3-((trimethylsilyl)oxy)pyrazine-2-carboxamide

Descrição

Applications 6-​Fluoro-​3-​[(trimethylsilyl)​oxy]​-2-​pyrazinecarboxamide is an intermediate in synthesizing T-705RTP (T003210), a derivative of T-705 (F103350) which has activity against the lethal H5N1 influenza A viruses. T-705RTP which has the triphosphate group, gets strongly inhibited by the influenza virus RNA polymerase activity in comparison with T-705RMP (T003202).
References Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005); Kiso, M., et al.: Proc. Natl. Acad. Sci. U.S.A., 107, 882 (2010);

• Marca: TRC

Propriedades químicas

• Peso molecular: 138.301
• Fórmula: C₈H₁₂FN₃O₂Si
• Cor/forma: Neat
• InChI: InChI=1S/C8H12FN3O2Si/c1-15(2,3)14-8-6(7(10)13)12-5(9)4-11-8/h4H,1-3H3,(H2,10,13)
• Chave InChI: InChIKey=TWTWFMUQSOFTRN-JOTLNHQDSA-M
• SMILES: [2H]C([2H])([2H])C([2H])([2H])[Mg]Br