Fmoc-Aph(Hor)-OH (~10% THF) (Degarelix intermediate)

CAS: 1253282-31-3

Ref. TR-F647563

Informação sobre produto

• Nome: Fmoc-Aph(Hor)-OH (~10% THF) (Degarelix intermediate)
• Sinónimos: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-[[[(4S)-hexahydro-2,6-dioxo-4-pyrimidinyl]carbonyl]amino]-L-Phenylalanine
• Marca: TRC
• Descrição: Applications Fmoc-Aph(Hor)-OH (CAS# 1253282-31-3) is an intermediate of degarelix, a pharmeceutical hormone used in the treatment of prostate cancer. Fmoc-Aph(Hor)-OH has been used as a building block in peptide elongation reactions.References Guryanov, I.; et al.: WO 2017103275 (2017); Takahashi, D.; et al.: Angew. Chem. Int. Ed., 56, 7803 (2017).

Propriedades químicas

• Peso molecular: 542.54
• Fórmula: C₂₉H₂₆N₄O₇
• Cor/forma: Neat
• InChI: InChI=1S/C29H26N4O7/c34-25-14-23(31-28(38)33-25)26(35)30-17-11-9-16(10-12-17)13-24(27(36)37)32-29(39)40-15-22-20-7-3-1-5-18(20)19-6-2-4-8-21(19)22/h1-12,22-24H,13-15H2,(H,30,35)(H,32,39)(H,36,37)(H2,31,33,34,38)/t23-,24-/m0/s1
• Chave InChI: InChIKey=TYZSMQUWFLKJFB-ZEQRLZLVSA-N
• SMILES: O=C1C[C@@H](C(=O)Nc2ccc(C[C@H](NC(=O)OCC3c4ccccc4-c4ccccc43)C(=O)O)cc2)NC(=O)N1