Fursultiamine Hydrochloride

CAS: 2105-43-3

Ref. TR-F865230

Informação sobre produto

• Nome: Fursultiamine Hydrochloride
• Sinónimos: N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]-formamide Monohydrochloride, N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]-formamide Monohydrochloride, TTFD Hydrochloride, Thiamin Tetrahydrofurfuryl Disulfide Hydrochloride, Thiamine Tetrahydrofurfuryl Disulfide Hydrochloride
• Marca: TRC

Descrição

Applications Fursultiamine was synthesized for the purpose of developing forms of thiamine with improved lipophilicity for treating vitamin B1 deficiency. In addition to its clinical indication of avitaminosis, fursultiamine has been studied in clinical trials for Alzheimer's disease and autistic spectrum disorders with positive but modest benefits. It has also been investigated in improving energy metabolism during exercise and reducing exercise-induced fatigue with conflicting results.
References Miura, S.: Nippon Ganka Gakkai Zasshi, 69, 792 (1965); Mimori, Y., et al.: Met. Brain Disease, 11, 89 (1996); Webster, M., et al.: Eur. J. Appl. Physiol. Occup. Physio., 75, 520 (1997)

Propriedades químicas

• Peso molecular: 435.00
• Fórmula: C₁₇H₂₇ClN₄O₃S₂
• Cor/forma: Neat
• InChI: InChI=1S/C17H26N4O3S2.ClH/c1-12(16(5-6-22)26-25-10-15-4-3-7-24-15)21(11-23)9-14-8-19-13(2)20-17(14)18;/h8,11,15,22H,3-7,9-10H2,1-2H3,(H2,18,19,20);1H/b16-12+
• Chave InChI: InChIKey=OPGOLNDOMSBSCW-PXJKFVASSA-N
• SMILES: C/C(=C(\CCO)SSCC1CCCO1)N(C=O)Cc1cnc(C)nc1N.Cl