Genistein 4'-β-D-glucopyranoside

CAS: 152-95-4

Ref. TR-G349975

Informação sobre produto

• Nome: Genistein 4'-β-D-glucopyranoside
• Sinónimos: 4H-1-Benzopyran-4-one, 3-[4-(ß-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-, Sophoricoside (6CI,7CI,8CI), 3-[4-(ß-D-Glucopyranosyloxy)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one, 4',5,7-Trihydroxyisoflavone 4'-ß-D-glucopyranoside, 5',7'-Dihydroxy-4'-glucosyloxyisoflavone, Genistein 4'-O-glucoside, Genistein, 4'-ß-D-glucopyranoside, 3-[4-(β-<span class="text-smallcaps">D</span>-Glucopyranosyloxy)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one, 4-(5,7-dihydroxy-4-oxo-4H-chromen-3-yl)phenyl alpha-L-gulopyranoside, 4-(5,7-dihydroxy-4-oxo-4H-chromen-3-yl)phenyl beta-D-glucopyranoside, 4H-1-Benzopyran-4-one, 3-[4-(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)phenyl]-5,7-dihydroxy-, 4′,5,7-Trihydroxyisoflavone 4′-β-<span class="text-smallcaps">D</span>-glucopyranoside, 5′,7′-Dihydroxy-4′-glucosyloxyisoflavone, Genistein 4′-O-glucoside, Genistein, 4′-β-<span class="text-smallcaps">D</span>-glucopyranoside, Sophoricoside

Descrição

Applications Genistein 4'-β-D-glucopyranoside is a metabolite of Genistein (G350000), which exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation.
References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992),

• Marca: TRC

Propriedades químicas

• Peso molecular: 432.38
• Fórmula: C₂₁H₂₀O₁₀
• Cor/forma: Neat
• InChI: InChI=1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-3-1-9(2-4-11)12-8-29-14-6-10(23)5-13(24)16(14)17(12)25/h1-6,8,15,18-24,26-28H,7H2/t15-,18-,19+,20-,21-/m1/s1
• Chave InChI: InChIKey=ISQRJFLLIDGZEP-IJFYFLOXSA-N
• SMILES: O=c1c(-c2ccc(OC3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc2)coc2cc(O)cc(O)c12