Hemin Chloride (Technical grade)

CAS: 16009-13-5

Ref. TR-H245648

Informação sobre produto

• Nome: Hemin Chloride (Technical grade)
• Sinónimos: 1,3,5,8-Tetramethyl-2,4-divinylporphine-6,7-dipropionic Acid ferrichloride Chloro[dihydrogen 3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]iron, Chlorohemin, Chloroprotoferriheme, Chloroprotohemin, Ferric Hemin, Ferriheme, Ferriheme Chloride, Ferriporphyrin Chloride, Ferriprotoporphyrin, Ferriprotoporphyrin IX, Ferriprotoporphyrin IX Chloride, Hemin, Hemin IX, Hemin Chloride, Iron(III) Protoporphyrin Chloride, KJB 003, Panhematin, Protoferriheme, Protohemin, Protohemin Chloride, Teichmann's Crystals, 1,3,5,8-Tetramethyl-2,4-divinylporphine-6,7-dipropionic acid ferrichloride, 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, iron complex, Chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]iron, Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-, dihydrogen, (SP-5-13)-, Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N²¹,N²²,N²³,N²⁴]-, dihydrogen, (SP-5-13)-, Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, hydrogen (1:2), (SP-5-13)-, Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, dihydrogen, (SP-5-13)-, Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, hydrogen (1:2), (SP-5-13)-, Ferric hemin, Ferriheme chloride, Ferriporphyrin chloride, Ferriprotoporphyrin IX chloride, Haemin, Hemin chloride, Hemina, Hemine, Iron(III) protoporphyrin chloride, Iron, chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]-, Kjb 003, Protohemin IX, Protohemin chloride, Teichmann's crystals, Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24)-, hydrogen (1:2), (SP-5-13)-, Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24)-, dihydrogen, (SP-5-13)-, Alkaline Hematin D-575, UNII-743LRP9S7N, AI3-18784, Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, dihydrogen, (SP-5-13)-, Ferrihaem, NSC 122707, Teichmanns crystals, CCRIS 7061, Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen

Descrição

Applications Hemin chloride is a porphyrin complex heme oxygenase-1 inducer with acts in cellular protection and control. At a concentration of 20 mM Hemin chloride demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. The compound has been observed to induce cGMP formation through induction of guanylate cyclase. Hemin chloride has been noted to stimulate calcium-dependent K+ channels and modulate fluid transport and Na+ in the loop of henle in rat studies. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes, hemin chloride demonstrated anti-apoptotic, antiinflamatory and antioxidant properties. Through reactive oxygen species of ERK
References Vanova, K. et al.: BMC Cancer., 16, 309 (2016); Wang, X. et al.: ACS App. Mat. Inter., 9, 25387 (2017);

• Marca: TRC

Propriedades químicas

• Peso molecular: 651.94
• Fórmula: C₃₄H₃₂ClFeN₄O₄
• Cor/forma: Neat
• InChI: InChI=1S/C34H32N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);1H;/q-2;;+3/p-1/b25-13-,28-15-,29-14-,32-16-
• Chave InChI: InChIKey=NWHZLEMLCGKIBR-ZGIJJEEBSA-M