N-Hydroxy-methoxy Methyl Tenofovir Alafenamide

Ref. TR-H254800

Informação sobre produto

• Nome: N-Hydroxy-methoxy Methyl Tenofovir Alafenamide
• Sinónimos: (2S)-Isopropyl 2-(((((1-(6-((((hydroxymethoxy)methoxy)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate
• Marca: TRC
• Descrição: Applications N-Hydroxy-methyl Methoxy Tenofovir Alfenamide is an impurity of Tenofovir (T018500) which is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

Propriedades químicas

• Peso molecular: 566.544
• Fórmula: C₂₄H₃₅N₆O₈P
• Cor/forma: Neat
• InChI: InChI=1S/C24H35N6O8P/c1-17(2)37-24(32)19(4)29-39(33,38-20-8-6-5-7-9-20)16-36-18(3)10-30-12-27-21-22(25-11-26-23(21)30)28-13-34-15-35-14-31/h5-9,11-12,17-19,31H,10,13-16H2,1-4H3,(H,29,33)(H,25,26,28)/t18?,19-,39?/m0/s1
• Chave InChI: InChIKey=NYHINPFEGOSNLB-JZYXWCBNSA-N
• SMILES: CC(C)OC(=O)[C@H](C)NP(=O)(COC(C)Cn1cnc2c(NCOCOCO)ncnc21)Oc1ccccc1