3Alpha-Hydroxydesoxy Artemether

CAS: 174097-70-2

Ref. TR-H939050

Informação sobre produto

• Nome: 3Alpha-Hydroxydesoxy Artemether
• Sinónimos: (2S,3R,3aS,6R,6aS,8R,9S,10aR,10bR)-Decahydro-2-methoxy-3,6,9-trimethyl-10aH-9,10b-epoxypyrano[4,3,2-jk][2]benzoxepin-8-ol, 3alpha-Hydroxydeoxyartemether,[2S-(2alpha,3alpha,3abeta,6beta,6abeta,8beta,9beta,10aalpha,10bbeta)]-Decahydro-2-methoxy-3,6,9-trimethyl-10aH-9,10b-Epoxypyrano[4,3,2-jk][2]benzoxepin-8-ol

Descrição

Applications A metabolite of Artemether (A777400) and derivative of the antimalarial drug Artemisinin (A777500). Studies suggest that it may display neurotoxicity in animals due to its interaction with iron.
References Smith, S.L. et al.: Neurotoxicology, 19, 557 (1998); Abourashed, E.A. et al.: J. Natur. Prod., 59, 251 (1996);

• Marca: TRC

Propriedades químicas

• Peso molecular: 298.375
• Fórmula: C₁₆H₂₆O₅
• InChI: InChI=1S/C16H26O5/c1-8-5-6-10-9(2)13(18-4)19-14-16(10)11(8)7-12(17)15(3,20-14)21-16/h8-14,17H,5-7H2,1-4H3/t8-,9-,10+,11+,12-,13-,14+,15-,16+/m1/s1
• Chave InChI: InChIKey=NYMSZZKRBMNKGP-YMSVXTLUSA-N
• SMILES: CO[C@@H]1O[C@H]2O[C@]3(C)O[C@@]24[C@@H](C[C@H]3O)[C@H](C)CC[C@H]4[C@H]1C