9-Hydroxymethyl-10-hydroxy Camptothecin

CAS: 175613-38-4

Ref. TR-H947055

Informação sobre produto

• Nome: 9-Hydroxymethyl-10-hydroxy Camptothecin
• Sinónimos: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-10-(hydroxymethyl)-, (S)- (9CI)
• CAS: 175613-38-4

Descrição

Applications 9-Hydroxymethyl-10-hydroxy Camptothecin, is a metabolite of Camptothecin (C175150), which is a topoisomerase inhibitor for cancer therapy.
References Wani, M.C., et al.: J. Med. Chem., 29, 2358 (1986), Miller, K.D., et al.: Invest. New Drugs, 22, 69 (2004), Punt, C.J.A., et al.: Eur. J. Cancer, 40, 1332 (2004), Wang, J.-Q., et al.: Bioorg. Med. Chem., 13, 549 (2005),

• Marca: TRC

Propriedades químicas

• Peso molecular: 394.38
• Fórmula: C₂₁H₁₈N₂O₆
• Cor/forma: Light Orange Colour Solid
• InChI: InChI=1S/C21H18N2O6/c1-2-21(28)14-6-16-18-10(7-23(16)19(26)13(14)9-29-20(21)27)5-11-12(8-24)17(25)4-3-15(11)22-18/h3-6,24-25,28H,2,7-9H2,1H3/t21-/m0/s1
• Chave InChI: InChIKey=WUKNBBKPIIZWRO-NRFANRHFSA-N
• SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(CO)c(O)ccc3nc2-1