a-Hydroxy-a-3-thienyl-2-thiopheneacetic Acid 9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester

CAS: 783273-13-2

Ref. TR-H961835

Informação sobre produto

• Nome: a-Hydroxy-a-3-thienyl-2-thiopheneacetic Acid 9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester

Descrição

Applications α-Hydroxy-α-3-thienyl-2-thiopheneacetic Acid 9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester is an impurity in the synthesis of Tiotropium Bromide (T444850), a muscarinic receptor antagonist. Bronchodilator.
References Rodgers, T. et al.: J. Med. Chem., 20, 591 (1977); Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994); Donohue, J. F., et al.: Chest, 122, 47 (2002); Profita, M., et al.: Allergy, 60, 1361 (2005); Dusser, D., et al.: Eur. Respir. J., 27, 547 (2006);

• Marca: TRC

Propriedades químicas

• Peso molecular: 377.48
• Fórmula: C₁₈H₁₉NO₄S₂
• Cor/forma: Neat
• InChI: InChI=1S/C18H19NO4S2/c1-19-12-7-11(8-13(19)16-15(12)23-16)22-17(20)18(21,10-4-6-24-9-10)14-3-2-5-25-14/h2-6,9,11-13,15-16,21H,7-8H2,1H3/t11-,12-,13?,15?,16?,18?/m1/s1
• Chave InChI: InChIKey=AZLIPRWXPRLJQF-QARSOXCNSA-N
• SMILES: CN1C2C[C@H](OC(=O)C(O)(c3ccsc3)c3cccs3)C[C@@H]1C1OC12