Hypothemycin

CAS: 76958-67-3

Ref. TR-H998480

Informação sobre produto

• Nome: Hypothemycin
• Sinónimos: [1aR-(1aR*,3S*,4S*,6Z,9S*,15bR*)]-1a,8,9,15b-Tetrahydro-3,4,12-trihydroxy-14-methoxy-9-methyl-3H-oxireno[k][2]benzoxacyclotetradecin-5,11(2H,4H)-dione, NSC 354462, f 152 D2
• CAS: 76958-67-3

Descrição

Applications Hypothemycin is a potent and selective inhibitor of threonine/tyrosine-specific kinase, MEK, and other protein kinases that contain a conserved cysteine residue in the ATP-binding site in in vitro studies.
References Zhao, A., et al.: J. Antibiotics, 52, 1086 (1999); Schirmer, A., et al.: Proc. Nat. Acad. Sci. U. S. A., 103, 4234 (2006); Winssinger, M., et al.: Chem. Comm., 1, 22 (2007)

• Marca: TRC

Propriedades químicas

• Peso molecular: 378.37
• Fórmula: C₁₉H₂₂O₈
• Cor/forma: White to Off-White Solid
• InChI: InChI=1S/C19H22O8/c1-9-4-3-5-12(20)17(23)14(22)8-15-18(27-15)11-6-10(25-2)7-13(21)16(11)19(24)26-9/h3,5-7,9,14-15,17-18,21-23H,4,8H2,1-2H3/b5-3-/t9-,14-,15+,17+,18+/m0/s1
• Chave InChI: InChIKey=WXKUAYVKUKAIQR-UHFFFAOYSA-N
• SMILES: Cn1nc(C(=O)OC(=O)c2nn(C)c3ccccc23)c2ccccc21