IMD 0354

CAS: 978-62-1

Ref. TR-I268650

Informação sobre produto

• Nome: IMD 0354
• Sinónimos: 5-Chloro-α,α,α,α',α',α'-hexafluoro-3',5'-salicyloxylidide N-(3,5-Bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide
• Marca: TRC
• Descrição: Applications IMD 0354 is an inhibitor of IKK β (IKK-2) and blocks Iκβα phosphorylation in the NF-κB pathway. IMD 0354 might also have therapeutic efficacy in the treatment of human mesothelioma.References Nishikawa, S., et al.: Cancer Med., 3, 416 (2014); Tanka., A., et al.: Blood, 105, 2324 (2005); Sugita. A., et al.: Int. Arch. Allergy Immunol, 148, 186 (2009); Kamon, J.M., et al.:Biochem., Biophys, Res. Commun,, 323, 242 (2004); Onai, et al.: Cardiovasc. Res., 63, 51 (2004)

Propriedades químicas

• Peso molecular: 383.67
• Fórmula: C₁₅H₈ClF₆NO₂
• Cor/forma: Neat
• InChI: InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
• Chave InChI: InChIKey=WOEHXCDLEYXISO-NMRJUBPYSA-N
• SMILES: C[C@@H]1C[C@H]2[C@H]3CC[C@@](O)(C4(C)OCCO4)[C@@]3(C)CC[C@H]2[C@@]2(C)CCC3(C[C@@]12O)OCCO3