exo-IWR-1

CAS: 1127442-87-8

Ref. TR-I941805

Informação sobre produto

• Nome: exo-IWR-1
• Sinónimos: rel-4-[(3aR,4R,7S,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide

Descrição

Applications exo-IWR-1 is the enantiomer of IWR-1 (I941800). exo-IWR-1 is an SAR anticancer Wnt response inhibitor. Such compounds may be used in the treatment of Wnt protein signaling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
References Lepourcelet, M., et al.: Cancer Cell, 5, 91 (2004), Barker, N., et al.: Nat. Rev. Drug Disc., 5, 997 (2006), Clevers, H., et al.: Cell, 127, 469 (2006), Jin, G., et al.: Bioorg. Med. Chem. Lett., 19, 606 (2009),

• Marca: TRC

Propriedades químicas

• Peso molecular: 409.437
• Fórmula: C₂₅H₁₉N₃O₃
• Cor/forma: Neat
• InChI: InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20+,21-
• Chave InChI: InChIKey=ZGSXEXBYLJIOGF-BTYSMDAFSA-N
• SMILES: O=C(Nc1cccc2cccnc12)c1ccc(N2C(=O)[C@H]3[C@@H]4C=C[C@@H](C4)[C@H]3C2=O)cc1