Leflunomide-d4

CAS: 1189987-23-2

Ref. TR-L322752

Informação sobre produto

• Nome: Leflunomide-d4
• Sinónimos: 5-Methylisoxazole-4-[4-trifluoromethylcarboxanilide]-d4, Leflunomida-d4, 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide-d4, Leflunomidum-d4
• CAS: 1189987-23-2

Descrição

Applications An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases.This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Vrenken, T., et al.: J. Hepatol., 49, 799 (2008), Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008), Davies, M., et al.: J. Med. Chem., 52, 2683 (2009),

• Marca: TRC

Propriedades químicas

• Peso molecular: 274.23
• Fórmula: C₁₂H₅D₄F₃N₂O₂
• Cor/forma: Neat
• InChI: InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)/i2D,3D,4D,5D
• Chave InChI: InChIKey=VHOGYURTWQBHIL-QFFDRWTDSA-N
• SMILES: [2H]c1c([2H])c(C(F)(F)F)c([2H])c([2H])c1NC(=O)c1cnoc1C