Levothyroxine Glucose Adduct

Ref. TR-L378055

Informação sobre produto

• Nome: Levothyroxine Glucose Adduct
• Sinónimos: 3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-2-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]amino]propanoic acid

Descrição

Applications Levothyroxine Glucose Adduct is a derivative of Thyroxine (T425600), which is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976); Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988); Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996); Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997)

• Marca: TRC

Propriedades químicas

• Peso molecular: 939.011
• Fórmula: C₂₁H₂₁I₄NO₉
• Cor/forma: Neat
• InChI: InChI=1S/C21H21I4NO9/c22-9-4-8(5-10(23)15(9)28)34-19-11(24)1-7(2-12(19)25)3-13(21(32)33)26-20-18(31)17(30)16(29)14(6-27)35-20/h1-2,4-5,13-14,16-18,20,26-31H,3,6H2,(H,32,33)/t13?,14-,16-,17+,18-,20-/m1/s1
• Chave InChI: InChIKey=RNJAPBOTPMXWGI-RGZZAEQBSA-N
• SMILES: O=C(O)C(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O