LGX 818

CAS: 1269440-17-6

Ref. TR-L397655

Informação sobre produto

• Nome: LGX 818
• Sinónimos: Carbamic acid, N-[(1S)-2-[[4-[3-[5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-methylethyl]-, methyl ester, (S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate, Encorafenib, NVP-LGX 818NXA, N-[(1S)-2-[[4-[3-[5-Chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-methylethyl]-carbamic Acid Methyl Ester, N-[(1S)-2-[[4-[3-[5-Chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-methylethyl]-carbamic Acid Methyl Ester, (S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate, Braftovi, Carbamic acid, N-[(1S)-2-[[4-[3-[5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-methylethyl]-, methyl ester, Lgx 818, Nvp-Lgx 818Nxa

Descrição

Applications LGX 818 is potent and selective BRAFV600E kinase inhibitor and can be used for the treatment of proliferative diseases such as solid tumor diseases.
References Huang, T., et al.: J. Hematol. Oncol., 6, 30 (2013); Stuart, D., et al.: PCT Int. Appl. (2013), WO 2013070996 A1 20130516

• Marca: TRC

Propriedades químicas

• Peso molecular: 540.01
• Fórmula: C₂₂H₂₇ClFN₇O₄S
• Cor/forma: White to Off-White Solid
• InChI: InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1
• Chave InChI: InChIKey=CMJCXYNUCSMDBY-ZDUSSCGKSA-N
• SMILES: COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1