Methotrexate

CAS: 59-05-2

Ref. TR-M260675

Informação sobre produto

• Nome: Methotrexate
• Sinónimos: N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid, L-(+)-N-[p-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-glutamic acid, (+)-Amethopterin, 4-Amino-10-methylfolic acid, 4-Amino-N10-methylfolic acid, 4-Amino-N10-methylpteroylglutamic acid, Amethopterin, Amethopterine, Antifolan, CL 14377, EMT 25299, Emtexate, L-Amethopterin, L-Methotrexate, Ledertrexate, MTX, Metatrexan, Methotrexat-Ebewe, Methoxtrexate, Methylaminopterin, Mexate, N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-(+)-glutamic acid, NSC 740, R 9985, Rheumatrex, Trexall, (+)-4-Amino-10-Methylfolic Acid, (2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic acid, 4-Amino-1, 4-Amino-4-Deoxy-N(Sup10, 4-Amino-4-Deoxy-N(Sup10)Methylpteroylglutamic Acid, 4-Amino-N 10-Methylpteroyl-L-Glutamic Acid, 4-Amino-N¹⁰-methylfolic acid, 4-Amino-N¹⁰-methylpteroylglutamic acid, <span class="text-smallcaps">L</span>-Amethopterin, <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">L</span>-Methotrexate, Caditrex, Cl 14377, Emt 25299, Emthexate PF, Emtrexate, Folex, Folex PFS, Folitrax, Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">L</span>-(+)-, Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-, Jylamvo, L-(+)-Amethopterin, L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, Merex, Methocel, Methocip, Methotrexat, Methotrexate LPF, Methylaminopterine, Methylpteroylglutamate, Methylpteroylglutamic Acid, Metorex, Metotrexato, Mexate-AQ, Mtx, N-(P-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Glutamic Acid, N-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid, N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid, N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-(+)-glutamic acid, Nordimet, Nsc 740, Oncotrex, Remtrex, Trilem, Zexate

Descrição

Stability Hygroscopic
Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),

• Marca: TRC

Propriedades químicas

• Peso molecular: 454.44
• Fórmula: C₂₀H₂₂N₈O₅
• Cor/forma: Yellow To Dark Yellow
• InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
• Chave InChI: InChIKey=FBOZXECLQNJBKD-ZDUSSCGKSA-N
• SMILES: CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1