(R)-3-Methylamino-1-(2-thienyl)-1-propanol

CAS: 116539-57-2

Ref. TR-M287170

Informação sobre produto

• Nome: (R)-3-Methylamino-1-(2-thienyl)-1-propanol
• Sinónimos: 2-Thiophenemethanol, a-[2-(methylamino)ethyl]-, (aR)-, 2-Thiophenemethanol, a-[2-(methylamino)ethyl]-, (R)-, (aR)-a-[2-(Methylamino)ethyl]-2-thiophenemethanol, (1R)-3-(Methylamino)-1-(2-thienyl)-1-propanol, (1R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-o, (R)-alpha-[2-(Methylamino)ethyl]-2-thiophenemethanol, (1R)-3-(Methylamino)-1-(2-thienyl)-1-propanol, (R)-(+)-3-(N-Methylamino)-1-(2-thienyl)-1-propanol
• CAS: 116539-57-2

Descrição

Applications (R)-3-Methylamino-1-(2-thienyl)-1-propanol is a reactant used in the synthesis of enantiomerically pure Duloxetine (D721000), an antidepressant. A dual serotonin and norepinephrine reuptake inhibitor (SNRI). Used in treatment of stress urinary incontinence.
References Wong, D.T., et al.: Neuropsychopharmacology, 8, 23 (1993), Fuller, R.W., et al.: J. Pharmacol. Exp. Ther., 269, 132 (1994), Sharma, A., et al.: J. Clin. Pharmacol., 40, 161 (2000)

• Marca: TRC

Propriedades químicas

• Peso molecular: 171.26
• Fórmula: C₈H₁₃NOS
• Cor/forma: Neat
• InChI: InChI=1S/C8H13NOS/c1-9-5-4-7(10)8-3-2-6-11-8/h2-3,6-7,9-10H,4-5H2,1H3/t7-/m1/s1
• Chave InChI: InChIKey=DXBHDBLZPXQALN-LFHVAVFRSA-N
• SMILES: CO[C@@H]1O[C@H](CO)C2OC(C)(C)OC21