Misonidazole

CAS: 13551-87-6

Ref. TR-M368700

Informação sobre produto

• Nome: Misonidazole
• Sinónimos: a-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol, a-(Methoxymethyl)-2-nitroimidazole-1-ethanol, 1-(2-Hydroxy-3-methoxypropyl)-2-nitroimidazole, 1-(2-Nitro-1-imidazolyl)-3-methoxy-2-propanol, 2-Nitro-1H-imidazole-1-(3-methoxy-2-propanol), NSC 261037, Racemic Misonidazole, Ro 7-0582, SR 1354, SRI 1354, 1-Methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol, Imidazole-1-ethanol, α-(methoxymethyl)-2-nitro-, Misonidazol, Nsc 261037, Racemic misonidazole, Sr 1354, Sri 1354, α-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol, Imidazole-1-ethanol, .alpha.- (methoxymethyl)-2-nitro-, 1-Methoxy-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol, 1H-Imidazole-1-ethanol, α-(methoxymethyl)-2-nitro-, 13551-87-6, .alpha.-(Methoxymethyl)-2-nitroimidazole-1-ethanol, 1-Methoxy-3-(2-nitro-1H-imidazol-1-yl)-2-propanol, 1H-imidazole-1-ethanol, alpha-(methoxymethyl)-2-nitro-, 1-Methoxy-3-(2-nitro-1-imidazolyl)-2-propanol, 1H-Imidazole-1-ethanol, .alpha.-(methoxymethyl)-2-nitro-

Descrição

Applications Misonidazole can be used as a potential hypoxic cancer cell radiosensitizer and DNA binding and nicking agent. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells
References Bonnet, M., et al.: Bioorg. Med. Chem., 22, 2123 (2014); Edwards, D.I.: Comprehensive Med. Chem., 2, 725 (1990); Murata, R., et al.: Radiother. Oncol., 87, 331 (2008); Brown, J.M. The mechanisms of cytotoxicity and chemosensitization by misonidazole and other nitroimidazoles. Int.J.Radiat.Oncol.Biol.Phys. 8(3-4), 675-682 (1982).

• Marca: TRC

Propriedades químicas

• Peso molecular: 201.180
• Fórmula: C₇H₁₁N₃O₄
• Cor/forma: Yellow Solid
• InChI: InChI=1S/C7H11N3O4/c1-14-5-6(11)4-9-3-2-8-7(9)10(12)13/h2-3,6,11H,4-5H2,1H3
• SMILES: COCC(O)Cn1ccnc1[N+](=O)[O-]