Nicergoline

CAS: 27848-84-6

Ref. TR-N394550

Informação sobre produto

• Nome: Nicergoline
• Sinónimos: Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv., Cergodum, Circo-Maren, Dilasenil, Duracebrol, Ergobel, Ergotop, FI 6714, MNE, Memoq, NSC 150531, Nicergolent, Nicotergoline, Sermion, TA 079, Vasospan, Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-, Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8β)- (9CI), Ergoline-8β-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI), Nicotinic acid, 5-bromo-, (10-methoxy-1,6-dimethylergolin-8β-yl)methyl ester (8CI)
• Marca: TRC
• Descrição: Applications Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)

Propriedades químicas

• Peso molecular: 484.39
• Fórmula: C₂₄H₂₆BrN₃O₃
• Cor/forma: White To Off-White
• InChI: InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1
• Chave InChI: InChIKey=YSEXMKHXIOCEJA-FVFQAYNVSA-N
• SMILES: CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13