NVP-AUY 922

CAS: 747412-49-3

Ref. TR-N925650

Informação sobre produto

• Nome: NVP-AUY 922
• Sinónimos: VER 52296, NVP-AUY922, 3-Isoxazolecarboxamide, 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-, 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide, 5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide, Auy 922, Luminespib, Nvp-Auy 922, Nvp-Auy 922Nx, Nvp-Auy922, Nvr-Auy 922, Ver 52296
• CAS: 747412-49-3

Descrição

Applications NVP-AUY 922 is a potent inhibitor of heat shock protein 90 (Hsp90) that prevents the proliferation of a range of human cancer cell lines. NVP-AUY 922 has been shown to enhance the radiation sensitivity of tumor cell lines under hypoxia. Potent Hedgehog inhibitor.
References Djuzenova, C.S. et al.: Cencer Biol. Ther., 13, 425 (2012); Lee, K.-K. et al.: Cancer Sci., 102, 1388 (2011); Okui, T. et al.: Anticancer Res., 31, 1197 (2011);

• Marca: TRC

Propriedades químicas

• Peso molecular: 465.54
• Fórmula: C₂₆H₃₁N₃O₅
• Cor/forma: Off-WHite to Pale Beige Solid
• InChI: InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)
• Chave InChI: InChIKey=NDAZATDQFDPQBD-UHFFFAOYSA-N
• SMILES: CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(CN2CCOCC2)cc1