11-Oxo Fluticasone Propionate

CAS: 1219174-94-3

Ref. TR-O856860

Informação sobre produto

• Nome: 11-Oxo Fluticasone Propionate
• Sinónimos: Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-16-methyl-3,11-dioxo-17-(1-oxopropoxy)-, S-(fluoromethyl) ester, (6a,16a,17a)-, 6a,9-difluoro-17-[[(fluoromethyl)sulfanyl]carbonyl]-16a-methyl-3,11-dioxoandrosta-1,4-dien-17a-yl propanoate, Fluticasone Propionate Imp. F (EP), GR 40775X, Ph Eur Fluticasone Propionate Impurity F, 11-keto fluticasone propionate (GR 40775X), unidentified impurity with RRT 1.23, disulphide dipropionate dithioketone (GR 247095X), dithio (GR 269949X), Compound A (fluticasone propionate related), [(6S,8S,9R,10S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate, Unii-Xo35Ctg0Yc

Descrição

Impurity Fluticasone EP Impurity F
Applications 11-Oxo Fluticasone Propionate is an impurity of Fluticasone Propionate (F599500), a derivative of Flumethasone (F455000). An antiallergic; anti-asthmatic; anti-inflammatory.
References Matuszewski, B, et al.: Anal. Chem., 75, 3019 (2003), Fekete, S., et al.: J. Pharm. Biomed. Anal., 49, 64 (2009), Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990), Mitchison, H.C., et al.: Gut, 32, 260 (1991), Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)

• Marca: TRC

Propriedades químicas

• Peso molecular: 498.56
• Fórmula: C₂₅H₂₉F₃O₅S
• Cor/forma: Off-White
• InChI: InChI=1S/C25H29F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,22+,23+,24+,25+/m1/s1
• Chave InChI: InChIKey=RGGLGWLQXMGICO-HOERUVBCSA-N
• SMILES: CCC(=O)O[C@]1(C(=O)SCF)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@@]21C