(S,S)-Palonosetron Diethylamide Dihydrochloride

Ref. TR-P165785

Informação sobre produto

• Nome: (S,S)-Palonosetron Diethylamide Dihydrochloride

Descrição

Applications (S,S)-Palonosetron Diethylamide Dihydrochloride is an intermediate in the synthesis of (S,S)-Palonosetron Acid which itself is an impurity in the synthesis of (S,S) Palonosetron (P165800), serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

• Marca: TRC

Propriedades químicas

• Peso molecular: 442.46
• Fórmula: C₂₃H₃₅N₃O•2HCl
• Cor/forma: White Solid
• InChI: InChI=1S/C23H35N3O.2ClH/c1-3-26(4-2)23(27)20-10-6-8-18-7-5-9-19(22(18)20)15-24-21-16-25-13-11-17(21)12-14-25;;/h6,8,10,17,19,21,24H,3-5,7,9,11-16H2,1-2H3;2*1H/t19-,21+;;/m1../s1
• Chave InChI: InChIKey=XSSBNYRDNZEWMT-ZKVWPJASSA-K
• SMILES: [Li]OP(=O)(O)O[C@H]1[C@H](O)[C@@H](OP(=O)(O)O[Li])[C@H](OP(=O)(O)O[Li])[C@@H](O)[C@H]1O