(R,R)-Palonosetron Hydrochloride

CAS: 135729-75-8

Ref. TR-P165805

Informação sobre produto

• Nome: (R,R)-Palonosetron Hydrochloride
• Sinónimos: 1H-Benz[de]isoquinolin-1-one, 2-(3R)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-, hydrochloride (1:1), (3aR)-, 1H-Benz[de]isoquinolin-1-one, 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-, monohydrochloride, [R-(R*,R*)]- (9CI), (3aR)-2-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one hydrochloride (1:1), RS 25259-198, S-(-)-3-Aminoquinuclidine 2HCl, (3aR)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one, (3R)-3-ammonio-1-azoniabicyclo[2.2.2]octane dichloride, (3aS)-2-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one, (S)-(-)-3-Amino Quinuclidine Dihcl, S-3-Aminoquinuclidine dihydrochloride, (S)-3-Aminoquinuclidine dihydrochloride

Descrição

Applications Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

• Marca: TRC

Propriedades químicas

• Peso molecular: 332.87
• Fórmula: C₁₉H₂₄N₂O·HCl
• Cor/forma: White To Off-White
• InChI: InChI=1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m0./s1
• Chave InChI: InChIKey=OLDRWYVIKMSFFB-NBLXOJGSSA-N
• SMILES: Cl.O=C1c2cccc3c2[C@@H](CCC3)CN1[C@H]1C[N@]2CC[C@@H]1CC2