Informação sobre produto
- Isoquinoline
- 1,2,3,4-tetrahydro-1-phenyl-
- (1R)-
- Isoquinoline
- 1,2,3,4-tetrahydro-1-phenyl-
- (R)-
- (-)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
- (1R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
- (1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline
Applications (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the counterpart to (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, the latter enantiomer being a key intermediate in the preparation of Solifenacin (S676700), an antimuscarinic agent. Since (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is produced as a by-product, it has been suggested that it should be recycled in order to obtain the S enantiomer on a larger scale. (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is also used as a reagent to prepare quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives, compounds that act as muscarinic receptor antagonists.
References Bolchi, C., et al.: Org. Process Res. Dev., 17, 432 (2013); Naito, R., et al.: J. Med. Chem., 48, 6597 (2005)
Propriedades químicas
Consulta técnica sobre: TR-P336925 (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
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