Pixantrone Dimaleate

CAS: 144675-97-8

Ref. TR-P552500

Informação sobre produto

• Nome: Pixantrone Dimaleate
• Sinónimos: Benz[g]isoquinoline-5,10-dione, 6,9-bis[(2-aminoethyl)amino]-, (2Z)-2-butenedioate (1:2), Benz[g]isoquinoline-5,10-dione, 6,9-bis[(2-aminoethyl)amino]-, (Z)-2-butenedioate (1:2), BBR 2778, Pixantrone maleate, 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione di[(2E)-but-2-enedioate], Bbr 2778, Benz[g]isoquinoline-5,10-dione, 6,9-bis[(2-aminoethyl)amino]-, (Z)-2-butenedioate (1:2), Pixantrone dimaleate, Pixolti, Pixuvri, Unii-P0R64C4Cr9
• CAS: 144675-97-8

Descrição

Applications Pixantrone is an antineoplastic drug belonging to group of antitumor antibiotics. Pixantrone is an anlogue of Mitoxantrone (M373425) and is just as potent in the treatment of multiple sclerosis with fewer toxic effects on cardiac tissue. Studies suggest that Pixantrone significantly reduces amyloid beta (A beta(1-42)) neurotoxicity, a mechanism implicated in Alzheimer's disease.
References Cavalletti, E. et al.: Invest. New Drugs, 25, 187 (2007); Gonsette, R.E. et al.: J. Neurol. Sci., 223, 81 (2004); Colombo, R. et al.: Electrophoresis, 30, 1418 (2009)

• Marca: TRC

Propriedades químicas

• Peso molecular: 557.51
• Fórmula: C₂₅H₂₇N₅O₁₀
• Cor/forma: Neat
• InChI: InChI=1S/C17H19N5O2.2C4H4O4/c18-4-7-21-12-1-2-13(22-8-5-19)15-14(12)16(23)10-3-6-20-9-11(10)17(15)24;2*5-3(6)1-2-4(7)8/h1-3,6,9,21-22H,4-5,7-8,18-19H2;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
• Chave InChI: InChIKey=SVAGFBGXEWPNJC-SPIKMXEPSA-N
• SMILES: NCCNc1ccc(NCCN)c2c1C(=O)c1ccncc1C2=O.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O