Ponatinib

CAS: 943319-70-8

Ref. TR-P688250

Informação sobre produto

• Nome: Ponatinib
• Sinónimos: Benzamide, 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-, 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide, AP 24534, Iclusig, Ap 24534, Ap24534, Benzamide, 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-, AP24534(Ponatinib)

Descrição

Applications Ponatinib is a tyrosine kinase inhibitors (TKI) and used to treat chronic myeloid leukemia (CML) (1,2,3). Ponatinib is also used in combination with other drugs, such as forskolin, to combat TKI resistance in patient with CML (3), targeted drug in small-cell lung cancer. Potent FAK inhibitor. FGFR/VEGFR/Bcr-Abl inhibitor It is a COVID19-related research product.
References (1) Poch, M. M., et al.: Expert Rev Hematol. 9, 923 (2016) (2) Shamroe, C. L. and Comeau, J. M. Ann Pharmacother. 47, 1540 (2013)(3) Oaxaca, D. M., et al.: Tumour Biol. 37, 12643 (2016)

• Marca: TRC

Propriedades químicas

• Peso molecular: 532.56
• Fórmula: C₂₉H₂₇F₃N₆O
• Cor/forma: Off-White
• InChI: InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
• Chave InChI: InChIKey=JAWLBKXHCNMEIJ-UHFFFAOYSA-N
• SMILES: Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12